From Book News, Inc.
The 15th edition of Harrison's is cited by Brandon/Hill as both an "initial purchase" and as part of a "minimal core collection." New to the 16th edition of this substantial work is a heightened focus on clinical practice, with emphasis given to the approach to the patient, differential diagnosis, treatment options, and disease prevention. Some topics are new or receive expanded treatment, including the immune system and HIV/AIDS, stem cell and gene transfer in clinical medicine, radiation therapy, Clostridium difficile-associated disease, bioterrorism, disease screening, perimenopausal management, hormone replacement therapy, end-of-life care, and a new multi- chapter section on critical care medicine. Of the staggering 379 chapters, 46 are new or by new authors and the remainder have been revised. The new edition also features color illustration throughout rather than the additional color atlas of earlier editions.Copyright © 2004 Book News, Inc., Portland, OR

Book Description
THE NEW COLOR OF MEDICINE HUNDREDS OF DIAGRAMS AND CLINICAL PHOTOS INTEGRATED INTO THE TEXT – FOR THE FIRST TIME IN FULL COLOR *This description refers to the single-volume of Harrison's Principles of Internal Medicine, 16/e. The Harrison's name is synonymous with internal medicine. HPIM continues to be the most authoritative and #1 selling medical textbook throughout the world. From its unique section on signs and symptoms through to the most comprehensive coverage of most all conditions seen by physician’s, Harrison's is the internal medicine reference of choice. Harrison's 16th Edition features new, expanded, revised and updated material on the key topics in medical practice today. From the latest research findings to up-to-the-minute advances in diagnostic and treatment methodologies, Harrison's puts the facts you need at your fingertips. The 16th Edition improves on a winning formula with: *State-of-the-art coverage of over 4,700 diseases and disorders—more than any other internal medicine text – in the areas of oncology and hematology; infectious diseases; cardiology; pulmonology; gastroenterology; clinical immunology; rheumatology; endocrinology; and neurology *A brand new full color format—665 full color drawings, 175 clinical and laboratory images, and hundreds of boxes, tables, and algorithms that use color to guide you to the information you need ASAP in everyday patient care *Thorough revision and updates of virtually all chapters *The addition of key new chapters – including extensive new coverage of Critical Care Medicine *145 algorithms for making accurate clinical decisions fast at the point of care *1,160 easy-access tables for immediate access to vital information and formulas *Cardinal manifestations of disease/signs and symptoms in 55 chapters (you’ll find yourself turning to this section over and over again). Here you will find all the major manifestations, such as fever, pain, aches and rash, presented in depth, with a referral that takes you to the disease section for the complete chapter. Stay a step ahead of everyday practice with the most authoritative, comprehensive, and useful guide to the entire spectrum of internal medicine.

About the Author
Dennis L. Kasper, M.D. William Ellery Channing Professor of Medicine Professor of Microbiology and Molecular Genetics Harvard Medical School Director, Channing Laboratory Department of Medicine Brigham and Women's Hospital Boston, Massaschusetts Eugene Braunwald, AB, MD, MA (Hon), MD (Hon), ScD (Hon) Distinguished Hersey Profesor of Medicine Harvard Medical School Chairman, TIMI Study Group Brigham and Women’s Hospital Boston, Massachussetts Anthony S. Fauci, MD Chief, Laboratory of Immunoregulation Director, National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda, MD Stephen L. Hauser, MD Robert A. Fishman Distinguished Professor and Chairman Department of Neurology University of California, San Francisco San Francisco, CA Dan L. Longo, MD Scientific Director National Institute on Aging National Institutes of Health Bethesda, MD J. Larry Jameson, MD Irving S. Cutter Professor and Chairman Department of Medicine Northwestern University Medical School Physician-in-Chief, Northwestern Memorial Hospital Chicago, IL

Without question, HPIM features the highest profile board of editors among the competition (both print and online). All are world-class investigator/clinicians. Each editor meticulously edits every chapter and two editors read overlapping chapters. The usual rotation of editors results in Dennis Kasper (the infectious disease editor) as editor-in-chief for this edition. An exception has been made to the retirement policy so that Dr. Braunwald will stay on the project for one last edition. Dr. Braunwald brings to the book tremendous creative energy, wide knowledge of all areas of medicine and incomparable institutional memory. He will also a key player at all the editorial meetings and will help shape the overall direction for this new edition. Dr. Anthony Fauci is one of the most visible medical names in the world through this past work in the AIDS field and current role in the fight against bioterrorism.

FROM THE PUBLISHER

Coming August 2004:The 16th Edition of HARRISON'S PRINCIPLES OF INTERNAL MEDICINE

THE NEW COLOR OF MEDICINE

HUNDREDS OF DIAGRAMS AND CLINICAL PHOTOS INTEGRATED INTO THE TEXT ￯﾿ﾽ FOR THE FIRST TIME IN FULL COLOR

A Step Ahead of Everyday Practice — the most authoritative, comprehensive, and useful guide to the entire spectrum of internal medicine￯﾿ﾽ Now in a 16th Edition that fully details the most exciting research and therapeutic advances in decades!

The new 16th Edition of Harrison's. puts at your fingertips unparalleled expert guidance for diagnosing, treating and managing thousands of disorders

Coverage and updates unmatched by any other resource.

With more than 3 million copies of previous editions sold worldwide, Harrison's is unquestionably the best-selling medical book ever. And with good reason. By virtue of its unrivalled comprehensiveness, timeliness, and ease of use￯﾿ﾽ the expertise of its renowned editors and contributors￯﾿ﾽ its invaluable guidelines for ensuring diagnostic accuracy￯﾿ﾽ and its state-of-the-art treatment strategies — Harrison's leads the way.

The 16th Edition improves on a winning formula with: *State-of-the-art coverage of over 4,700 diseases and disorders—more than any other internal medicine text ￯﾿ﾽ in the areas of oncology and hematology; infectious diseases; cardiology; pulmonology; gastroenterology; clinical immunology; rheumatology; endocrinology; and neurology *A brand new full color format—665 full color drawings, 175 clinical and laboratory images, and hundreds of boxes, tables, and algorithms that use color to guide you to the information you need ASAP in everyday patient care *Thorough revision and updates of virtually all chapters *The addition of key new chapters ￯﾿ﾽ including extensive new coverage of Critical Care Medicine *145 algorithms for making accurate clinical decisions fast at the point of care *1,160 easy-access tables for immediate access to vital information and formulas *Cardinal manifestations of disease/signs and symptoms in 55 chapters (you'll find yourself turning to this section over and over again). Here you will find all the major manifestations, such as fever, pain, aches and rash, presented in depth, with a referral that takes you to the disease section for the complete chapter

￯﾿ﾽLearners and practitioners at every level and in virtually every specialty will find it useful￯﾿ﾽ.the editors have assembled an impressive array of individual chapter authors￯﾿ﾽ￯﾿ﾽ*

THE 16TH EDITION'S DISTINGUISHED EDITORIAL BOARD: world-recognized authorities in their respective fields

Dennis L. Kasper, M.D. William Ellery Channing Professor of Medicine Professor of Microbiology and Molecular Genetics Harvard Medical School Director, Channing Laboratory Department of Medicine Brigham and Women's Hospital Boston, Massachusetts

Eugene Braunwald, AB, MD, MA (Hon), MD (Hon), ScD (Hon) Distinguished Hersey Professor of Medicine Harvard Medical School Chairman, TIMI Study Group Brigham and Women's Hospital Boston, Massachusetts

Anthony S. Fauci, MD Chief, Laboratory of Immunoregulation Director, National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda, MD

Stephen L. Hauser, MD Betty Anker Fife Professor and Chairman Department of Neurology University of California, San Francisco San Francisco, CA

Dan L. Longo, MD Scientific Director National Institute on Aging National Institutes of Health Bethesda, MD

J. Larry Jameson, MD Irving S. Cutter Professor and Chairman Department of Medicine Northwestern University Medical School Physician-in-Chief, Northwestern Memorial Hospital Chicago, IL

*Online reviews of the previous edition

￯﾿ﾽI am a dual resident in Emergency medicine and internal medicine. I have studied from many medical texts in my training and its rare that you find a book that teaches you while you read it instead of just facts presented on a page. Harrison's is, in my opinion the root for all medicine board questions, and I would trust no other text for my career in internal medicine.￯﾿ﾽ*

￯﾿ﾽThe bottom line￯﾿ﾽis that if you are an Internist, you need Harrison's.￯﾿ﾽ*

￯﾿ﾽ[Harrison's] is a must-have for the internist, medical student or anyone who needs in-depth medical information at their fingertips.￯﾿ﾽ*

HERE'S WHAT'S NEW IN THE 16TH EDITION

Harrison's 16th Edition features new, expanded, revised and updated material on the key topics in medical practice today. From the latest research findings to up-to-the-minute advances in diagnostic and treatment methodologies, Harrison's puts the facts you need at your fingertips. Here's just a sample of what you'll find:

CRITICAL CARE Critical care units — cardiac, general medicine, respiratory, neurological ￯﾿ﾽ represent a growing percentage of in-hospital beds. With 10 chapters in three sections, this is a major and timely addition

DISEASE SCREENING AND PREVENTION You'll find principles and guidelines for screening for common disorders such as cancer, hypertension, lipid disorders, and osteoporosis. These screening approaches should be considered by every internist for routine health maintenance

WOMEN'S HEALTH An updated overview of practical approaches to the diagnosis and management of disorders and diseases unique to women

SEXUAL DYSFUNCTION Now addresses management of sexual dysfunction in women as well as men

DISORDERS OF LIPOPROTEIN METABOLISM Greater focus on the classification, diagnosis, and treatment of disorders of cholesterol and triglyceride metabolism. Features updated treatment guidelines with a focus on the use of statins for reducing cardiovascular risk

ALZHEIMER'S AND RELATED DEMENTIAS Summarizes the explosion of knowledge in an easily readable style. Presents a clinical guide to the diagnosis of Alzheimer's; how to distinguish Alzheimer's from other dementia problems; and the very latest clinical recommendations on the use of new treatments for dementia

PARKINSON'S DISEASE Reviews all the new findings in applied and clinical genetics, and provides an authoritative approach to therapeutics including surgical options

MICROBIAL, CHEMICAL, AND RADIATION BIOTERRORISM The medical profession is on the front line of response to threats of bioterrorism. These chapters were written by recognized experts and edited by Dr. Anthony Fauci who leads the government's biomedical efforts towards national preparedness against such attacks. They are clear and succinct with easily readable charts, tables and algorithms to help you understand the pathogenesis, diagnosis, treatment and prognosis of the diseases in question. No other general medical reference covers all of these important subjects in such a comprehensive and clear manner

HIV/AIDS This revision of what is widely considered to be the classic treatment of this topic fully reflects the rapid evolution of medical knowledge of HIV disease, particularly the all-important advances in therapeutic strategies. This chapter's clinically practical nature and its comprehensive and analytical approach to the pathogenesis of HIV disease make it a complete reference on HIV/AIDS

IMMUNE SYSTEM Another truly classic treatment, this chapter has now been updated to include the rapid advances in both basic and clinical immunology. It combines an in-depth description and analysis of the principles of basic immunology with an easy flow into the application of these principles to clinical disease states.

DISORDERS OF IMMUNE-MEDIATED INJURY Major advances in immunomodulatory therapy realized in rheumatology over the past three years have been captured in extensive revisions in chapters on Rheumatoid Arthritis, Systemic Lupus Erythematosus, and The Spondyloarthropathies

PSEUDOMEMBRANOUS COLITIS due to Clostridium difficile This important pathogen is a very frequently encountered organism, especially in the hospital setting

STEM CELL AND GENE TRANSFER Defines different types of stem cells, and discusses potential applications in clinical medicine ranging from bone marrow transplantation to future possibilities such as stem cell transplantation in the heart, pancreatic islets, and central nervous system. There is also a major focus on how gene transfer can be combined with stem cells to modify their function

PERIMENOPAUSE TRANSITION AND HORMONE REPLACEMENT THERAPY Timely chapter addresses the controversial topic of hormone therapy. Coincides with publication of the results of the Women's Health Initiative, which unexpectedly showed increased cardiovascular risk in women receiving estrogen treatment. Provides practical algorithms for managing the care of women during and after the menopause transition

DISORDERS OF SEXUAL DIFFERENTIATION Highlights new insights derived from the genetic basis of sex determination

BONE AND MINERAL METABOLISM Incorporates the vast number of new insights into bone development and turnover. An outstanding review that lays the foundation for understanding the pathophysiology and treatment of various metabolic bone diseases

PLUS ￯﾿ﾽ the latest evidence and guidance on the prevention of stroke￯﾿ﾽ new developments in the treatment of multiple sclerosis￯﾿ﾽ vital updates in the fields of neurology and psychiatry￯﾿ﾽ breakthrough advances in the treatment of viral hepatitis￯﾿ﾽ and much more.

SYNOPSIS