From Scientific American
It would be hard to imagine two more different timescales in the lives of organisms than development--the transformation of an embryo to an adult within a single generation--and evolution--the modification and transformation of organisms between generations that reach back 600 million years. Yet for the past two centuries, natural philosophers, morphologists and biologists have asked whether there is a fundamental relationship between development (ontogeny) and evolution (phylogeny). There is, and it finds expression in the thriving discipline of evolutionary developmental biology (evo devo, as it has been called since the early 1990s). Endless Forms Most Beautiful examines one of the most exciting aspects of evo devo--the incorporation of molecular biology that followed the discovery of classes of conserved regulatory (developmental, or "switching") genes: the homeobox, or Hox, genes. Carroll, who is a professor of genetics at the University of Wisconsin–Madison, writes in a lively style, peppering the book with endlessly fascinating examples that are beautifully illustrated by color and black-and-white drawings and photographs. To appreciate where this latest book devoted to evo devo is situated in the long history of the discipline, we need to go back almost 200 years. The study of embryonic stages across the animal kingdom--comparative embryology--flourished from 1830 on. Consequently, when On the Origin of Species appeared in 1859, Charles Darwin knew that the embryos of all invertebrates (worms, sea urchins, lobsters) and vertebrates (fish, serpents, birds, mammals) share embryonic stages so similar (which is to say, so conserved throughout evolution) that the same names can be given to equivalent stages in different organisms. Darwin also knew that early embryonic development is based on similar layers of cells and similar patterns of cell movement that generate the forms of embryos and of their organ systems. He embraced this community of embryonic development. Indeed, it could be argued that evo devo (then known as evolutionary embryology) was born when Darwin concluded that the study of embryos would provide the best evidence for evolution. Darwin's perception was given a theoretical basis and evo devo its first theory when Ernst Haeckel proposed that because ontogeny (development) recapitulates phylogeny (evolutionary history), evolution could be studied in embryos. Technological advances in histological sectioning and staining made simultaneously in the 1860s and 1870s enabled biologists to compare the embryos of different organisms. Though false in its strictest form, Haeckel's theory lured most morphologists into abandoning the study of adult organisms in favor of embryos--literally to seek evolution in embryos. History does repeat itself; 100 years later a theory of how the body plan of a fruit fly is established, coupled with technological advances, ushered in the molecular phase of evo devo evaluated by Carroll. As Carroll discusses in his book (the title of which comes from the last lines of The Origin of Species), the discovery of Mendelian genetics in 1900, and soon after of the gene as the unit of heredity, thrust a wedge between development and evolution. Genes were now what mattered in evolution; embryos were merely the vehicles that carried genes from one generation to the next. Embryology was divorced from evolution, devo from evo. Even the discovery in the 1950s of the nature and role of DNA did not bring them back together. In the late 1970s, however, all began to change as several revolutions in theory and technology produced a mind shift as dramatic as the one that followed Darwin's The Origin of Species. New methods for generating phylogenetic relationships brought comparative embryology back to the forefront; now we can assess the direction of evolutionary changes in development. When we find a species of frog that has lost the tadpole stage from its life cycle--a remarkable evolutionary change in form and function--we can determine whether that loss was an early or late event in the evolution of frogs. Stephen Jay Gould's seminal book Ontogeny and Phylogeny (1977) rekindled interest in 19th-century evolutionary embryology and resurrected an old idea--heterochrony, change in the timing of development in a descendant relative to an ancestor--in a form that could be tested. Important as these developments were, they were carried out against the then current wisdom that organisms differ because they possess unique genes not found in other organisms--lobster genes for lobsters, human genes for humans, and so forth. The discovery of homeobox genes turned this approach upside down and inside out. The body plans of lobsters and humans, flies and fish, barnacles and mice, are initiated using the same families of genes that are conserved across the animal kingdom. The consequences of this discovery are the stuff of the first half of Endless Forms Most Beautiful, in which Carroll presents homeobox genes as the switches that contain the fundamental information required to make a fly's eye or a human hand. The second half of the book explores what Carroll calls "the making of animal diversity," beginning with animal life as exemplified in the justly famous 500-million-year-old fossils of the Burgess Shale formation in British Columbia. Carroll is concerned with evolutionary tinkering with genetic switches and the production of patterns in nature--spots on butterfly wings, stripes on zebras. He devotes less attention to the downstream gene cascades and gene networks that allow similar signaling genes to initiate, for example, the wing of a bird or a human arm. Nor are the cells and cellular processes from which the endless forms are constructed given prominence. Consequently, statements such as "the anatomy of animal bodies is really encoded and built ... by constellations of switches distributed all over the genome" could be taken to mean that switching genes contain all the information required to generate form. Were that true there would be no need for evo devo; indeed, there would be no development. It would all be geno evo. But, as Carroll demonstrates, "the evolution of form occurs through changes in development," which is precisely why evo devo is so central to understanding how animals have been and are being evolved.

Brian K. Hall is George S. Campbell Professor of Biology and a University Research Professor at Dalhousie University in Halifax. He is author of Evolutionary Developmental Biology and of Bones and Cartilage: Developmental and Evolutionary Skeletal Biology, among other books, and co-editor with Benedikt Hallgrímsson of the forthcoming Variation: A Central Concept in Biology.


From Booklist
*Starred Review* Evo Devo is short for evolutionary developmental biology, a new science that explores the biological processes that give rise to both the shared traits and the wild diversity of animal anatomies. Carroll is at the vanguard of this promising field, and he is also a lucent and lively popular science writer deeply inspired by the order, ingenuity, and beauty of the molecular choreography he brings to light. Evo Devo has not only proven that human beings have a surprising number of genes in common with other animals, including the humble fruit fly, it has also revealed the startling fact that every animal species on earth is derived from the same small set of "tool-kit genes." In explicating these unexpected discoveries, Carroll describes in stunning detail the geography of a growing embryo, how genes mark out a diagram of the body to come, and how exactly, thanks to "genetic switches," the "hotspots of evolution," one group of genes can produce such variations on a theme as butterflies, birds, leopards, and whales. Carroll's highly detailed and well-illustrated technical discussions are enriched by his appreciation for the philosophical, aesthetic, and ethical implications of the biological wonders he decodes, adding up to a vital and enjoyable introduction to a field with profound implications. Donna Seaman
Copyright © American Library Association. All rights reserved


Book Description
What Brian Greene did for string theory, Sean Carroll—a leading biologist—does for Evo Devo. Evo Devo is evolutionary developmental biology, the third revolution in evolutionary biology. The first was marked by the publication of The Origin of Species. The second occurred in the early twentieth century, when Darwin's theories were merged with the study of genetics. Now the insights of Evo Devo are astonishing the biology world by showing how the endless forms of animals—butterflies and zebras, trilobites and dinosaurs, apes and humans, are made and evolved. Perhaps the most surprising finding of Evo Devo is the discovery that a small number of primitive genes led to the formation of fundamental organs and appendages in all animal forms. The gene that causes humans to form arms and legs is the same gene that causes birds and insects to form wings, and fish to form fins; similarly, one ancient gene has led to the creation of eyes across the animal kingdom. Changes in the way this ancient tool kit of genes is used have created all the diversity that surrounds us. Sean Carroll is the ideal author to lead the curious on this intellectual adventure—he is the acknowledged leader of the field, and his seminal discoveries have been featured in Time and The New York Times. 16 pages of color and 100 black-and-white illustrations.


About the Author
Sean B. Carroll is an investigator at the Howard Hughes Medical Institute and professor of genetics at the University of Wisconsin-Madison. He lives in Madison, Wisconsin.

FROM THE PUBLISHER

"The greatest spectacle of life is how a single cell - the fertilized egg - develops into a billion- or trillion-celled animal. In the case of humans, that single cell becomes the most complex machine in existence. Scientists have long known that if they could figure out how form and pattern emerge in embryos, they could begin to understand how today's incredibly diverse animal kingdom evolved from primitive forms over 600 million years ago. For over a century, then, opening the black box of the embryo has been the Holy Grail of biology." "The box has finally been unbolted. And Evo Devo - evolutionary developmental biology - is the new scientific crowbar that accomplished the feat. In the pages of Endless Forms Most Beautiful, Sean B. Carroll, one of the pioneers of Evo Devo, explains this astounding scientific revolution." Researchers now know that life's building materials are few, and they were "invented" near the dawn of animals. More specifically, a surprisingly small number of genes - "tool kit genes" - are the primary components for building all animals, and these genes emerged at a time before the Cambrian Explosion, some 600 million years ago. Thus the amazing diversity of the animal kingdom is the result of the flexibility of a small number of building blocks that have existed for eons.

FROM THE CRITICS

Library Journal

Carroll (genetics, Univ. of Wisconsin, Madison) has written the first book for general readers on the emerging field of evolutionary developmental biology, a.k.a. "evo devo," the study of how the shapes and forms of animals and humans have developed and evolved. Besides being an important researcher at his institution, where he works on butterfly eyespot development, Carroll is also a gifted writer. In a breathtakingly effortless manner, he builds on complex concepts, e.g., that a few primitive genes gave rise to the formation of essential organs and appendages in all animals. His topic is crucial, involving the recent and profound contributions of embryology and development to our understanding of the evolution of life's diversity. These are key components of evolutionary theory that advance the conceptual "Modern Synthesis" of population genetics and paleontology of the 1930s and 1940s. In light of this new understanding, the objections to evolutionary theory based on transitional gaps and irreducible complexity become more obtuse than ever. More accessible than Rudolf A. Raff's fine pioneering work, The Shape of Life, this book belongs in all libraries. [See the Q&A with Carroll on p. 107; see also Prepub Alert, LJ 12/04.-Ed.]-Walter L. Cressler, West Chester Univ. Lib., PA Copyright 2005 Reed Business Information.

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