From Book News, Inc.
Comprises 18 contributions on common inherited diseases such as heart disease, asthma, and cancer. Covers topics such as statistical methods pertaining to mapping genetic diseases, generating data in the lab, and public databases and mapping resources. Specific topics include basic concepts of linkage analysis, collecting biological samples for DNA analysis, database design for gene mapping studies, genomic screening, affected relative pair analyses, and examining complex genetic interactions. Book News, Inc.®, Portland, OR


Review
"The book provides a useful compendium of information for those who wish to embark on gene mapping studies. The editors are to be commended on taking on such a difficult task." --Analytical Biochemistry, Volume 270, 1999


Book Description
Approaches to Gene Mapping in Complex Human Diseases

Edited by Jonathan L. Haines and Margaret A. Pericak-Vance

Recent years have seen a tremendous growth in statistical and laboratory methods for genetic mapping -a process by which we discover genes that contribute to heart disease, hypertension, diabetes, asthma, cancer, and other complex genetic disorders not controlled by a single gene.

Approaches to Gene Mapping in Complex Human Diseases is the first book devoted to the analysis of such common, inherited diseases. This text helps the reader sort through the plethora of available resources, choose the best methodology for a given problem, and design successful gene mapping projects from the ground up. In eighteen chapters, compiled by two of the leading figures in the field, this book covers a wide range of topics -from the process of selecting families to the testing of candidate genes. It provides indispensable information on:
* Genetic concepts and statistics pertaining to mapping genetic disease
* Issues involved in collecting and handling biological samples and data
* Strategies for generating data in the lab
* Methods of analysis such as Lod score, Sib-pair, or Affected Relative-Pair
* Public databases and mapping resources
* Sources of statistical and genetic information, software, and documentation.

Approaches to Gene Mapping in Complex Human Diseases clearly explains concepts and design procedures while keeping technical details to a minimum. For geneticists, clinicians, molecular biologists, epidemiologists, and anyone interested in the pursuit of genes, it provides a solid grounding in the fundamentals and facilitates a firm grasp of the most advanced procedures and techniques available.


Book Info
Vanderbilt Univ., Nashville, TN. Text devoted to the analysis of commonly inherited diseases. Explains concepts and design procedures while keeping technical details to a minimum. For geneticists, clinicians, molecular biology, and epidemiologists. DNLM: Hereditary Diseases--genetics.


The publisher, John Wiley & Sons
By emphasizing concepts and design rather than focusing on technical details, this book prepares the researcher to use all available resources intelligently and efficiently. Introductory chapter puts readers from diverse backgrounds on equal footing. Information about public databases, mapping resources and where to find theoretical information, software, and documentation are all presented.


From the Back Cover
Approaches to Gene Mapping in Complex Human DiseasesEdited by Jonathan L. Haines and Margaret A. Pericak-VanceRecent years have seen a tremendous growth in statistical and laboratory methods for genetic mapping —a process by which we discover genes that contribute to heart disease, hypertension, diabetes, asthma, cancer, and other complex genetic disorders not controlled by a single gene.Approaches to Gene Mapping in Complex Human Diseases is the first book devoted to the analysis of such common, inherited diseases. This text helps the reader sort through the plethora of available resources, choose the best methodology for a given problem, and design successful gene mapping projects from the ground up. In eighteen chapters, compiled by two of the leading figures in the field, this book covers a wide range of topics —from the process of selecting families to the testing of candidate genes. It provides indispensable information on: Genetic concepts and statistics pertaining to mapping genetic disease Issues involved in collecting and handling biological samples and data Strategies for generating data in the lab Methods of analysis such as Lod score, Sib-pair, or Affected Relative-Pair Public databases and mapping resources Sources of statistical and genetic information, software, and documentation.Approaches to Gene Mapping in Complex Human Diseases clearly explains concepts and design procedures while keeping technical details to a minimum. For geneticists, clinicians, molecular biologists, epidemiologists, and anyone interested in the pursuit of genes, it provides a solid grounding in the fundamentals and facilitates a firm grasp of the most advanced procedures and techniques available.

ANNOTATION

The book contains black-and-white illustrations.

By emphasizing concepts and design rather than focusing on technical details, this book prepares the researcher to use all available resources intelligently and efficiently. Unlike books that merely present recipes for tomorrow's assay, this book guides the reader in shaping long term research plans for the months and years ahead. Introductory chapter puts readers from diverse backgrounds on equal footing. The chapters on gentic concepts and statistics are presented in the context of mapping human genetic disease. The issues involved in proper selection of families and the collection and handling of samples and data are clearly explained. Information about public databases, mapping resources, and where to find theoretical information, software, and documentation are all presented.

FROM THE PUBLISHER

Approaches to Gene Mapping in Complex Human Diseases is the first book devoted to the analysis of common, inherited diseases. This text helps the reader sort through the plethora of available resources, choose the best methodology for a given problem, and design successful gene mapping projects from the ground up. In eighteen chapters, compiled by two of the leading figures in the field, this book covers a wide range of topics - from the process of selecting families to the testing of candidate genes. Approaches to Gene Mapping in Complex Human Diseases clearly explains concepts and design procedures while keeping technical details to a minimum. For geneticists, clinicians, molecular biologists, epidemiologists, and anyone interested in the pursuit of genes, it provides a solid grounding in the fundamentals and facilitates a firm grasp of the most advanced procedures and techniques available.

FROM THE CRITICS

Michael Cummings

The Human Genome Project has accelerated the rate at which new genes are identified and mapped. As a result, genes controlling hundreds of traits have been mapped, and in most cases, the responsible gene has been isolated, cloned, and studied. However, not all human genetic traits are controlled by single genes. Many common conditions such as hypertension, diabetes, schizophrenia, and manic depression are complex traits, involving several genes as well as environmental components. New techniques for mapping the genes controlling these complex traits have been developed and are gathered into this book, providing a comprehensive overview of this process. The authors propose to provide a resource for researchers who want to map or understand the methods used in mapping. This is a guide to basic scientists, clinicians, and other researchers interested in mapping complex traits. The contributors are all experts working in the field who, along with the editors, have produced a book that will allow researchers to design and carry out experiments in mapping complex traits. Rather than concentrate on the theoretical basis of mapping, the chapter contributors emphasize the design, establishment of phenotypes, the use of family and sib pair ascertainment techniques, the collection of biological samples for analysis, methods of genotyping, and the use of software programs and databases for mapping. Anyone interested in mapping complex human diseases or wishing to understand how to use score analysis, microsatellite markers, sib pair analysis, affected relative pair analysis, and other modern methods of gene mapping should have this book at hand. It is a comprehensive, up-to-date handbook forgene mapping in humans. This book belongs in every library with a collection on human genetics, and on the bookshelf of everyone interested in human gene mapping.

Doody Review Services

Reviewer: Michael Cummings, PhD (University of Illinois at Chicago)Description: The Human Genome Project has accelerated the rate at which new genes are identified and mapped. As a result, genes controlling hundreds of traits have been mapped, and in most cases, the responsible gene has been isolated, cloned, and studied. However, not all human genetic traits are controlled by single genes. Many common conditions such as hypertension, diabetes, schizophrenia, and manic depression are complex traits, involving several genes as well as environmental components. New techniques for mapping the genes controlling these complex traits have been developed and are gathered into this book, providing a comprehensive overview of this process. Purpose: The authors propose to provide a resource for researchers who want to map or understand the methods used in mapping. Audience: This is a guide to basic scientists, clinicians, and other researchers interested in mapping complex traits. The contributors are all experts working in the field who, along with the editors, have produced a book that will allow researchers to design and carry out experiments in mapping complex traits. Features: Rather than concentrate on the theoretical basis of mapping, the chapter contributors emphasize the design, establishment of phenotypes, the use of family and sib pair ascertainment techniques, the collection of biological samples for analysis, methods of genotyping, and the use of software programs and databases for mapping. Assessment: Anyone interested in mapping complex human diseases or wishing to understand how to use score analysis, microsatellite markers, sib pair analysis, affected relative pair analysis, and other modern methods of gene mapping should have this book at hand. It is a comprehensive, up-to-date handbook for gene mapping in humans. This book belongs in every library with a collection on human genetics, and on the bookshelf of everyone interested in human gene mapping.

Booknews

Comprises 18 contributions on common inherited diseases such as heart disease, asthma, and cancer. Covers topics such as statistical methods pertaining to mapping genetic diseases, generating data in the lab, and public databases and mapping resources. Specific topics include basic concepts of linkage analysis, collecting biological samples for DNA analysis, database design for gene mapping studies, genomic screening, affected relative pair analyses, and examining complex genetic interactions. Annotation c. by Book News, Inc., Portland, Or.

RATING

4 Stars! from Doody

ACCREDITATION