Review
"...the field of neuroscience is in the professor's debt for writing it...worth the read." Neurology
Book Description
Conventional wisdom assumes that sleep is a resting state of the brain, with negligible activity of cortical neurons. Here, the author brings new evidence favoring the idea that during sleep, memory traces acquired while awake are consolidated. Mircea Steriade focuses on the coalescence of different sleep rhythms in interacting corticothalamic networks and on three types of paroxysmal disorders: spike-wave seizures as in absence epilepsy, Lennox-Gastaut seizures, and temporal-lobe epilepsy. Many physiological correlates of waking and sleep states as well as diverse types of epileptic seizures are also discussed.
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Different states of vigilance and various paroxysmal disorders that occur during slow-wave sleep can have the same neural bases. Conventional wisdom holds that sleep is a resting state of the brain, with negligible activity of cortical neurons. Here, the author brings new evidence favoring the idea that during this behavioral state memory traces acquired during waking are consolidated. The author focuses on the coalescence of different sleep rhythms in interacting corticothalamic networks and on three types of paroxysmal disorders, namely spike-wave seizures as in absence epilepsy, Lennox-Gastaut seizures, and temporal-lobe epilepsy. Many physiological correlates of waking and sleep states as well as diverse types of epileptic seizures are also discussed. The book has copious illustrations with examples from in vivo, in vitro and 'in computo' studies, the majority coming from the author's own laboratory. Neuronal Substrates of Sleep and Epilepsy is essential reading for neuroscientists and clinical researchers.
Book Info
Examines the neuronal mechanisms underlying sleep stages and different forms of paroxysmal activities occurring during states of drowsiness and slow-wave sleep. Many physiological correlates of waking and sleep states as well as diverse types of epileptic seizures are discussed. Addresses the coalescence of different sleep rhythms. For neuroscientists.
Neuronal Substrates of Sleep and Epilepsy FROM THE PUBLISHER
Neuronal circuits between the neocortex, the thalamus, the hippocampus and related systems underlie the different states of vigilance and various paroxysmal disorders that occur during slow-wave sleep. The author challenges the conventional idea that slow-wave sleep is a quiescent state with negligible activity of cortical neurons and brings evidence, based on intracellular recordings in vivo and more recently in naturally sleeping animals, demonstrating that neocortical neurons are quite active during this sleep state. The activity of neocortical neurons during sleep contributes to plasticity, which may lead to consolidation of memory traces acquired during the waking state. The author focuses on the coalescence of different sleep rhythms in interacting corticothalamic networks and on three types of paroxysmal disorders; namely, spike-wave seizures as in absence epilepsy, Lennox-Gastaut seizures, and temporal lobe epilepsy. Profusely illustrated with figures from in vivo, in vitro and 'in computo' studies, the majority coming from the author's own laboratory, Neuronal Substrates of Sleep and Epilepsy is essential reading for neuroscientists and clinical researchers.
Art & Photography
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