Book Description
Signal Transduction in Leukocytes presents important principles and various aspects of cellular regulation in leukocytes. The book discusses receptor structure and signaling, emphasizing cytokine receptors and the T cell and B cell antigen receptors. It investigates the role of the heterotrimeric G proteins and small G proteins as transducers.Authorities in each field cover a wide range of topics. They explore propagation of signaling cascades through second messengers and serine/threonine kinases, the initiation of signaling from the B and T cell antigen receptors by tyrosine phosphorylation and protein recruitment, and the role of signaling in cell-cell interactions and the regulation of the cell cycle. The book outlines the relationship of receptor signaling to inflammatory reactions of neutrophils, eosinophils, and macrophages.

ANNOTATION

The book contains black-and-white illustrations.

FROM THE PUBLISHER

Signal Transduction in Leukocytes presents important principles andvarious aspects of cellular regulation in leukocytes. The book discusses receptor structure and signaling, emphasizing cytokine receptors and the T cell and B cell antigen receptors. It investigates the role of the heterotrimeric G proteins and small G proteins as transducers.

Authorities in each field cover a wide range of topics. They explore propagation of signaling cascades through second messengers and serine/threonine kinases, the initiation of signaling from the B and T cell antigen receptors by tyrosine phosphorylation and protein recruitment, and the role of signaling in cell-cell interactions and the regulation of the cell cycle. The book outlines the relationship of receptor signaling to inflammatory reactions of neutrophils, eosinophils, and macrophages.

FROM THE CRITICS

Alvin Telser

This is a comprehensive review of signal transduction pathways in leukocytes, primarily lymphocytes and eosinophils. The emphasis is on G-protein pathways, but other pathways are also discussed. It consists of ten chapters and an index, carefully edited by three experts in the field. The editors describe this as a book for students, teachers and ""peers."" Signal transduction is an important area of research and new knowledge, so their goals are worthwhile and well attained. The writing style and content of the book is such that a beginner and an expert would both derive useful information from reading it. The editors of this volume are not known to me, but appear to be experts in the field and have brought other well-known researchers together to contribute to the book. Illustrations are not a major feature of this book. However, there are many illustrations consisting of diagrams of G-protein complexes and DNA sequences as well as tables and figures. The graphics serve their intended pedagogic purpose. The book has a thorough table of contents and index. The appendix, which contains many tables listing the components of signaling pathways, would serve as a useful resource for knowledgeable beginners in the field. There is also a lengthy list of abbreviations used in the book. Each chapter is very well referenced, with no chapter having fewer than about 120 references and one having nearly 600 citations. This book is not only a useful review of the state of knowledge of signal transduction in leukocytes, but it also contains considerable information on signal transduction in general. It is primarily a reference book, and libraries should have it on their shelves.

Doody Review Services

Reviewer: Alvin Telser, PhD (Northwestern University Medical School)Description: This is a comprehensive review of signal transduction pathways in leukocytes, primarily lymphocytes and eosinophils. The emphasis is on G-protein pathways, but other pathways are also discussed. It consists of ten chapters and an index, carefully edited by three experts in the field. Purpose: The editors describe this as a book for students, teachers and "peers." Signal transduction is an important area of research and new knowledge, so their goals are worthwhile and well attained. Audience: The writing style and content of the book is such that a beginner and an expert would both derive useful information from reading it. The editors of this volume are not known to me, but appear to be experts in the field and have brought other well-known researchers together to contribute to the book. Features: Illustrations are not a major feature of this book. However, there are many illustrations consisting of diagrams of G-protein complexes and DNA sequences as well as tables and figures. The graphics serve their intended pedagogic purpose. The book has a thorough table of contents and index. The appendix, which contains many tables listing the components of signaling pathways, would serve as a useful resource for knowledgeable beginners in the field. There is also a lengthy list of abbreviations used in the book. Each chapter is very well referenced, with no chapter having fewer than about 120 references and one having nearly 600 citations. Assessment: This book is not only a useful review of the state of knowledge of signal transduction in leukocytes, but it also contains considerable information on signal transduction in general. It is primarily a reference book, and libraries should have it on their shelves.

RATING

3 Stars from Doody

ACCREDITATION

Lad, Pramod M., MS, PhD (Kaiser Foundation Hospitals); Kaptein, John S., MSc, PhD (Kaiser Foundation Hospitals); Lin, Ching-Kow E., MS, PhD (Kaiser Foundation Hospitals)