From Book News, Inc.
Reviews the neuroanatomic, neurochemical, and molecular mechanisms that contribute to major psychiatric illnesses. The first two chapters provide a background for understanding neuronal signaling pathways and functional neural circuitry. The six clinical chapters summarize current knowledge on the neural circuitry, signaling pathways, and psychopharmacology of six disorders--schizophrenia, addiction, anxiety, depression, bipolar disorder, and Alzheimer's disease are covered.Copyright © 2004 Book News, Inc., Portland, OR

Book Description
The 1990s, appropriately termed "the decade of the brain," witnessed unprecedented advances in our knowledge of psychiatric neuroscience. Yet with every advance, we realized afresh that we were still in the beginning stages of a much longer journey. This text chronicles the next step of that journey. Structured around a proven teaching methodology that uniquely integrates the clinical aspects of psychiatric disorders with their neurobiology, this volume begins with two introductory chapters on functional neural circuitry and neural signaling pathways. The remaining six chapters present current knowledge on the neuroanatomic and neurochemical mechanisms underlying schizophrenia, addiction, anxiety, depression, bipolar disorder, and dementia/Alzheimer's disease. For clarity and consistency, each chapter features the same four divisions—clinical presentation, neural circuitry, signaling pathways, and psychopharmacology—as they relate to Schizophrenia, which reviews studies of the neural basis of schizophrenia and describes how the cortex, the thalamus, the basal ganglia, and the medial temporal lobe work together during normal brain function and then how each is perturbed in psychosis. Addiction, which focuses on the consequences of psychoactive substance use, including compulsive practices (e.g., eating, sex, Internet browsing) that might also involve the same brain circuits and signaling pathways. Of exceptional value are two unique illustrations that capture—for the first time—much of what we know about the anatomy and neurochemistry underlying the behavioral symptoms of addiction. Anxiety, which presents current hypotheses regarding neurocircuitry and signaling pathways for the three best-studied (from a neurobiologic perspective) anxiety disorders: panic disorder, posttraumatic stress disorder, and obsessive-compulsive disorder. Depression, which offers evidence for the involvement of highly interconnected cortical and limbic structures such as the prefrontal cortex, medial thalamus, amygdala, ventral striatum, hippocampus, and the hypothalamic-pituitary-adrenal axis in unipolar major depression, and suggests target areas (such as the cAMP pathway) for study in the development of new antidepressants. Bipolar disorder, which shows that specific abnormalities in signal transduction pathways, including protein kinase activity, G protein levels, and gene expression, are unique to bipolar patients, concluding that the actions of lithium and anticonvulsants on intracellular signaling pathways provide a new paradigm for novel pharmacological interventions. Dementia and Alzheimer’s disease, which details current findings on neurofibrillary degeneration, relevant genes and proteins, pathogenesis (metabolic decline, defective cell repair, and Aß toxicity), and treatment strategies (neurotransmitter replacement, and neuroprotective and regenerative approaches). Discusses frontotemporal dementia, dementia with Lewy bodies, Parkinson’s disease, and vascular dementia. Meticulously researched and clearly written by 15 contributors—all recognized experts from leading research and teaching institutions in the United States—this compact and extensively illustrated volume stands out in the literature because it combines readability and practicality with the breadth and depth typically found only in far lengthier works. Psychiatric practitioners, residents, and students alike will welcome this informative, easy-to-read text, which will also be of special interest to mental health and pharmaceutical industry professionals, and of general interest to anyone who wants to know more about the biology of psychiatric illness.

Book Info
Provides a review of contemporary facts and opinion of neural connections relevant to psychiatric disorders and their pharmacological treatment. Includes definitions and diagrams. For students and practitioners. DNLM: Biological Psychiatry--methods.

About the Author
Gary B. Kaplan, M.D., is Associate Professor in the Departments of Psychiatry and Human Behavior and Molecular Pharmacology, Physiology, and Biotechnology at Brown University School of Medicine and Veterans Affairs Medical Center in Providence, Rhode Island. Ronald P. Hammer Jr., Ph.D., is Professor in the Departments of Psychiatry, Anatomy, Pharmacology, and Neuroscience at Tufts University School of Medicine and Laboratory of Research in Psychiatry, New England Medical Center in Boston, Massachusetts.

FROM THE CRITICS

Doody Review Services

Reviewer: Michael J. Schrift, DO (The Chicago Medical School)Description: This is a new book covering the use of computer technology in psychiatry. Written and edited by experts in the field, this book is a valuable contribution to psychiatry. Purpose: The purpose, according to the editors, is to focus on computer applications relevant to the practice of clinical psychiatry and provide an introductory reference for clinicans who are either new to computers or contemplating purchasing one for the first time. The editors have succeeded in producing a very useful guide for the computer novice. Audience: The intended audience is psychiatrists with basic or no knowledge of computer technology. It could also be useful for psychiatry residents. Features: The book features 169 pages divided into 11 chapters. Topics covered include chapters on choosing a computer, desktop and notebook computers, PDAs, software, the Internet, telemedicine, security issues, and the future. There is also a useful glossary and index section. There are helpful references at the end of each chapter. Assessment: This is a valuable new book summarizing thre state-of-the-art in psychiatric computer technology for the beginner.

Booknews

Reviews the neuroanatomic, neurochemical, and molecular mechanisms that contribute to major psychiatric illnesses. The first two chapters provide a background for understanding neuronal signaling pathways and functional neural circuitry. The six clinical chapters summarize current knowledge on the neural circuitry, signaling pathways, and psychopharmacology of six disorders—schizophrenia, addiction, anxiety, depression, bipolar disorder, and Alzheimer's disease are covered. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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