From Publishers Weekly
The difficult choices a family must make when a child is diagnosed with a serious disease are explored with pathos and understanding in this 11th novel by Picoult (Second Glance, etc.). The author, who has taken on such controversial subjects as euthanasia (Mercy), teen suicide (The Pact) and sterilization laws (Second Glance), turns her gaze on genetic planning, the prospect of creating babies for health purposes and the ethical and moral fallout that results. Kate Fitzgerald has a rare form of leukemia. Her sister, Anna, was conceived to provide a donor match for procedures that become increasingly invasive. At 13, Anna hires a lawyer so that she can sue her parents for the right to make her own decisions about how her body is used when a kidney transplant is planned. Meanwhile, Jesse, the neglected oldest child of the family, is out setting fires, which his firefighter father, Brian, inevitably puts out. Picoult uses multiple viewpoints to reveal each character's intentions and observations, but she doesn't manage her transitions as gracefully as usual; a series of flashbacks are abrupt. Nor is Sara, the children's mother, as well developed and three-dimensional as previous Picoult protagonists. Her devotion to Kate is understandable, but her complete lack of sympathy for Anna's predicament until the trial does not ring true, nor can we buy that Sara would dust off her law degree and represent herself in such a complicated case. Nevertheless, Picoult ably explores a complex subject with bravado and clarity, and comes up with a heart-wrenching, unexpected plot twist at the book's conclusion. Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.

From School Library Journal
Adult/High School - Anna was genetically engineered to be a perfect match for her cancer-ridden older sister. Since birth, the 13-year-old has donated platelets, blood, her umbilical cord, and bone marrow as part of her family's struggle to lengthen Kate's life. Anna is now being considered as a kidney donor in a last-ditch attempt to save her 16-year-old sister. As this compelling story opens, Anna has hired a lawyer to represent her in a medical emancipation suit to allow her to have control over her own body. Picoult skillfully relates the ensuing drama from the points of view of the parents; Anna; Cambell, the self-absorbed lawyer; Julia, the court-appointed guardian ad litem; and Jesse, the troubled oldest child in the family. Everyone's quandary is explicated and each of the characters is fully developed. There seems to be no easy answer, and readers are likely to be sympathetic to all sides of the case. This is a real page-turner and frighteningly thought-provoking. The story shows evidence of thorough research and the unexpected twist at the end will surprise almost everyone. The novel does not answer many questions, but it sure raises some and will have teens thinking about possible answers long after they have finished the book. - Susan H. Woodcock, Fairfax County Public Library, Chantilly, VA Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.

From Booklist
*Starred Review* Expect to be kept up all night by Picoult's latest novel, but it's much more than a page-turner; it's a fascinating character study framed by a complex, gripping story. Thirteen-year-old Anna Fitzgerald walks into the office of lawyer Campbell Alexander and announces she wants to sue her parents for the rights to her own body. Anna was conceived after her older sister, Kate, developed a rare form of leukemia at the age of two, and has donated bone marrow and blood to her sister. Now she has been asked to donate a kidney, and she intends to refuse. Campbell is a jaded young man who nevertheless decides to take her case pro bono. Anna's parents are shocked when they learn of her lawsuit, and her mother, a former civil defense attorney, decides to represent them. Anna refuses to budge on her position despite the fact that she clearly loves her sister and longs for her family's happiness. As the gripping court case builds, the story takes a shocking turn. Told in alternating perspectives by the engaging, fascinating cast of characters, Picoult's novel grabs the reader from the first page and never lets go. This is a beautiful, heartbreaking, controversial, and honest book. Kristine Huntley
Copyright © American Library Association. All rights reserved

FROM OUR EDITORS

The Barnes & Noble Review
Known for writing novels with provocative themes centered on family conflict and difficult moral choices, Jodi Picoult presents the story of a child whose sole reason for existence is to assure a genetic match for her terminally ill sibling.

Conceived in vitro, 13-year-old Anna Fitzgerald has decided to sue her parents to stop them from using her as "spare parts" for her older sister, Kate, who suffers from leukemia. After years of having her bone marrow and blood used to keep Kate alive, Anna now refuses to donate a kidney and strives for her own personal freedom. She hires lawyer Campbell Alexander to represent her, even as her own mother, a former civil defense attorney, fights her in court.

The complex and emotionally wrenching narrative unfolds from the alternating perspectives of a large cast of intriguing and likable characters. Picoult, who has handled such delicate topics as teen suicide and euthanasia in previous novels, proves equally adept with this sensitive and emotionally charged subject matter. The tragic circumstances of Anna's plight are made all the more poignant because it's clear from the onset how much she loves her family. In My Sister's Keeper, the author has crafted a compelling story that is heartbreaking and literate in equal measure.

FROM THE PUBLISHER

New York Times bestselling author Jodi Picoult is widely acclaimed for her keen insights into the hearts and minds of real people. Now she tells the emotionally riveting story of a family torn apart by conflicting needs and a passionate love that triumphs over human weakness.

Anna is not sick, but she might as well be. By age thirteen, she has undergone countless surgeries, transfusions, and shots so that her older sister, Kate, can somehow fight the leukemia that has plagued her since childhood. The product of preimplantation genetic diagnosis, Anna was conceived as a bone marrow match for Kate -- a life and a role that she has never challenged...until now. Like most teenagers, Anna is beginning to question who she truly is. But unlike most teenagers, she has always been defined in terms of her sister -- and so Anna makes a decision that for most would be unthinkable, a decision that will tear her family apart and have perhaps fatal consequences for the sister she loves.

My Sister's Keeper examines what it means to be a good parent, a good sister, a good person. Is it morally correct to do whatever it takes to save a child's life, even if that means infringing upon the rights of another? Is it worth trying to discover who you really are, if that quest makes you like yourself less? Should you follow your own heart, or let others lead you? Once again, in My Sister's Keeper, Jodi Picoult tackles a controversial real-life subject with grace, wisdom, and sensitivity.

FROM THE CRITICS

The Washington Post

Picoult is at her best, and most moving, when writing from the perspective of Anna's mother, Sara. Exhausted by Kate's recurrent illness, Sara is often on edge and overwhelmed. But she is also focused: Her tenacity, her vigilance and her support during Kate's aggressive cancer treatments all give Kate a reason to live. Mothering takes on new meaning, and the mundane becomes surreal: Kate's goldfish, according to the oceanologist Sara consults in a desperate effort to save the pet's life, requires bottled water, and the mere thought of buying Jesse a new pair of soccer cleats after Kate relapses seems "downright obscene." — Katherine Arie

Publishers Weekly

The difficult choices a family must make when a child is diagnosed with a serious disease are explored with pathos and understanding in this 11th novel by Picoult (Second Glance, etc.). The author, who has taken on such controversial subjects as euthanasia (Mercy), teen suicide (The Pact) and sterilization laws (Second Glance), turns her gaze on genetic planning, the prospect of creating babies for health purposes and the ethical and moral fallout that results. Kate Fitzgerald has a rare form of leukemia. Her sister, Anna, was conceived to provide a donor match for procedures that become increasingly invasive. At 13, Anna hires a lawyer so that she can sue her parents for the right to make her own decisions about how her body is used when a kidney transplant is planned. Meanwhile, Jesse, the neglected oldest child of the family, is out setting fires, which his firefighter father, Brian, inevitably puts out. Picoult uses multiple viewpoints to reveal each character's intentions and observations, but she doesn't manage her transitions as gracefully as usual; a series of flashbacks are abrupt. Nor is Sara, the children's mother, as well developed and three-dimensional as previous Picoult protagonists. Her devotion to Kate is understandable, but her complete lack of sympathy for Anna's predicament until the trial does not ring true, nor can we buy that Sara would dust off her law degree and represent herself in such a complicated case. Nevertheless, Picoult ably explores a complex subject with bravado and clarity, and comes up with a heart-wrenching, unexpected plot twist at the book's conclusion. (Apr.) Copyright 2004 Reed Business Information.

Library Journal

Imagine that you were conceived to be the donor of bone marrow and platelets for your older sister, who has a rare form of cancer. Imagine what it would be like to grow up in a family where everyone is constantly aware of one child's deadly illness, so that all decisions must be filtered through what will work for her treatment or her most recent medical emergency. How can a 12-year-old decide against donating a kidney to her older sister? By having this story narrated by each character in turn, Picoult (Second Glance) shows readers the dilemmas facing everyone involved: from Anna, the child who sues her parents for medical emancipation; to Sara, the mother who loves all three of her children but must devote continual attention to the daughter with cancer; and to Jesse, the son who has abandoned hope of ever being noticed by his parents. Picoult's timely and compelling novel will appeal to anyone who has thought about the morality of medical decision making and any parent who must balance the needs of different children. Highly recommended.-Kim Uden Rutter, Lake Villa Dist. Lib., IL Copyright 2004 Reed Business Information.

Kirkus Reviews