We are entering a new era of understanding the lymphatic system brought about by important insights from experimental investigations and clinical trials. To achieve a cure, cancer therapies (whether by surgery, radiotherapy or systemic means) must be directed against the routes of cancer spread. The management of the regional lymphatics/lymph nodes, often the first site of involvement, is frequently a key decision in defining modern treatment programs. Important new insights now challenge the basis of traditional cancer therapy recommendations. This volume brings together foremost authorities to outline the latest results in the management of the lymphatic system in cancer. Aggressive therapy or no treatment? Radiotherapy, surgery or systemic therapy? Combined modality or single modality therapy? For all major cancers - head and neck, lung, breast, gastrointestinal, genitourinary, gynecologic - current controversies are highlighted and specific recommendations for clinical treatment programs are clearly defined.